Tuesdays are Your Turn – Dulera vs. Advair

Here’s a little something different – one of the search questions that often lead people here:

Is Dulera safer than Advair?

Dulera, you’ll recall, is a new combination inhaler. As far as I can tell, it represents Merck’s attempt to corner a share of the long-acting beta agonist market rather than a “better” medication choice but as you may also recall, I’m no scientist.

Anyone got better information than me? Links? Opinions?

Dulera vs. Advair: your thoughts.

110 responses to “Tuesdays are Your Turn – Dulera vs. Advair”

  1. Rena says:

    If they would just give us our inhalers back without the HFA, We wouldn’t need any other asthma meds…..OZONE MY @$$

  2. Kelley says:

    Rena – I totally have to agree with you on wanting the old inhalers back.

  3. Melissa says:

    Funny you should ask that. I have a heart defect, and my asthma doc. recently had me try Dulera…I’ve been on advair for years, take half a dose, and have 6 months of back up inhalers. So I went back on Advair. Personally, I couldn’t really tell much difference, and the fomoterol part of Dulera always made me nervous anyways.

  4. kerri says:

    From what I’ve heard, supposedly formoterol is a “better” LABA than salmeterol [in Advair]. However, Pulmicort is apparently a weaker steroid [what’s in Symbicort now], so perhaps they’re trying different mixes for different people [which I am SO in favour of, considering I seem to be one of those people who needs a fair amount of Pulmicort with my formoterol to pull me into some semblance of control!

    FloVent and QVar are supposed to be the “stronger” inhaled steroids, I think. So the new mix and matching is rather exciting — though I don’t think Dulera has made it to Canada yet.

  5. Amy says:

    Oh I completely missed that possibility of matching patients to meds, Kerri. Great point! LABAs are one of those topics that I just don’t have any firsthand knowledge of since AG’s lucky enough not to need them. Thanks!

  6. Natasha says:

    I’ve recently moved from seretide (advair, by its European name) to separate LABA (formoterol) and steroid (ciclesonide) inhalers, and I have to say that I’m personally very happy with that move.

    For me, I like the flexibility of knowing that if I have to change dosages, as happened a few times whilst on seretide, that it doesn’t require getting a prescription for a different inhaler, as it did in the past. It also gives the flexibility to change components independently, to find the best match for each patient personally.

    Whilst I don’t have a flexible plan right now that allows for stepping up/down components, I like the idea that maybe that will be possible in the future.

    As an adult, I appreciate the flexibility here a lot, though I can imagine that with a child compliance might be more of an issue with taking an extra inhaler.

  7. Rena says:

    Yes since the FDA changed the Proventil inhalers to HFA, My asthma is no longer under control. That’s all I ever needed and now it doesn’t help at all. So now my Doctor has me doing Prednisone, Symbicort, Dulera, Nasonex and I also have the breathing machine for Albuterol Sulfate. Also I now have to go to a lung doctor. All these other drugs lead to death, it says it right on the lables, except for the Albuterol Sulfate. They say they took them off the market because of the ozone…..This is a bunch of crap they took them off so they could make more money off of all the other meds.

  8. Sarah says:

    @ Rena Actually, the FDA and drug companies had little to do with the decision to remove CFC inhalers from the market. The push for that was the EPA, which mandated with the Clean Air Act that the CFC inhalers be phased out as soon as alternatives were available.

    Regarding Dulera and separate LABA/steroid inhalers… Advair works fine for me, when I’m not flaring, and then I have to add steroid, not subtract it. I haven’t gotten lower that 500mcg BID of fluticasone in nearly two years (and even when I was lower, I shouldn’t have been) so it doesn’t bug me. If my asthma ever lessens enough that stepping down the steroid is a realistic option, I’ll speak to my doctor about it. As for Dulera, I might try it, if my doctor brings it up, but I’m relatively stable now and I’m reluctant to mess with what seems to be working.

  9. Kat says:

    Dulera does NOT work at all for me… I will stick to my Advair 500/50. I’ve been on it ever since it came out and I love it. I prefer the diskus over the HFA. As far as my Rescue inhaler (albuterol) is concerned. I want the old one back. HFA doesn’t work as well. I have tried Pro Air, Proventil and Ventolin. Proventil and Ventolin work better because you dont have to keep priming them if you dont use it for a while. But I say bring the old ones back. Clean up the air pollution and we won’t have as much asthma.

  10. Chris says:

    Dulera is very new to me, and I have not come across anyone locally using it. As to the two ingredient, it’s basically Asmanex (Mometasone) and Foradil (Formoterol) mixed together. In the studies I’ve read it seems to be very comparable to Advair. I did read though that the Fluticasone in Advair does have less systemic effects when compared to Mometasone because it seems to be a more receptor specific steroid. But the Formoterol seems to be slightly superior to the Salmeterol in Advair due to it’s faster onset time. The down side is that it seems to have more severe systemic side effects ( the Jitters.). I guess it all boils down to what works best for you. At the very least it gives all of us asthmatics a bigger choice in controller meds.

  11. Chris says:

    Hello again,
    I just wanted to chime in again about all the controversy surrounding the CFC to HFA conversion. I’ve been told by many patients that the HFA inhalers do not work like their “old” ones did. As for me I really never noticed a difference. The thing I don’t understand is that the medication is still exactly the same in the new inhalers, the only thing that was changed was the propellant. The only difference that I personally noticed is that the HFA inhalers don’t seem to squirt with as much force as the old CFC inhalers did, but that might just be my imagination, who knows.

  12. jean stigers says:

    I have used all inhalers on the market but dulera 200mcg/5mcg is great. 2 puffs in am I can go to the gym I have no breathing problems, then 1-2 puffs in the evening. It is like I have new lungs. My doctor has given me 2 samples and a perscription. My doctor had to contact the Ins. co. to get their ok, but I have never got the prescriptions filled. The cost is too high. The doctor gave me a discount card but he didn’t read it. The card said if you are on medicare or medicare part D, the discount card would be void. So even though Dulera really helps the cost is so high, and on a fixed income we can’t afford it.

  13. Bart says:

    Dulera hasn’t been on the market for terribly long, so the actual safety and adverse events reported to the FDA may take a while to get a handle on.

    The component of these medications that has been most worrysome and that carries the black box warning is the long acting beta agonist (LABA)

    In Advair, it’s the drug salmeterol
    In Dulera, it’s formoterol

    Here is a link to a few hardcore clinical studies if anyone cares to “geek out” a bit:


    While the main study that led to the black box warning was the SMART study – which looked specifically at salmeterol (found in Advair), the FDA extended the warning to the other products in the class.

    There have never been any significant clinical data comparing the safety of the two products head-to-head.

  14. nycgirl56 says:

    This is a great blog on asthma. I have allergies and certain things in my environment were triggering my asthma. Unbeknownst to me, the house I was living in had mold. The doctor put in on Advair which has a steroid in it and I took it for the whole 5 years I was living in the house. Once I moved away from the house, I noticed I not longer experienced dilibitatin asthma attacks, but what I did notice is that my body was still reacting to chest tightening when the advair wore off. After doing much reasearch, I found that I can’t just stop taking a steroid without experiencing a horrific asthma attack even though I was not longer exposed to the allergins that initially triggered my asthma. It took me almost 2 months to get myself off the Advair by slowy reducing the number of times I took. I was finally able to get off it completely. While I believe these meds are necessary for some people who suffer from COPD, I am concerned that these steroids are making people more dependent on them due to the steroid affect on the body, instead of working with an allergist to help build up immunities. I never will take a steroid again I rather try to treat my allergies alternatively. I now have side effects from taking it for so many years and have a catarack in m right eye, I’ve experienced a mild stroke, and some decreased bone density. I really think people need to know how these steroids adversely affect their asthama long-term.

  15. cathy says:

    Inhaled steroids, such as advair, are inhaled and exhaled, and therefore do not stay in the body and cause debilating side effects, such as brittle bones, cataracts, thinning of the skin, etc. However, oral steroids such as prednisone, taken over a long period of time can. I was prednisone dependent for almost twenty years and went from 135 lbs. to almost 300lbs., cataracts in both eyes, depression, and bone degeneration, and severe mood swings. After an extended hospital stay (one of many), I found a wonderful pulmonary doctor who was able to finally get me off the oral steroids. But the physical damage was done. I now take advair, singulair, albuterol, and an inhaled nasal steroid and am doing much better. I do have breakthroughs from time to time and my doctor will put me on an oral steroid dosepak that I taper down on. I can only hope that I never have to go back on daily steroids. I was much younger then and don’t think my body could handle it now.

  16. Former Researcher/current patient says:

    I just got switched from Advair to Dulera. All my research has led to me to find that they are equally as safe (or not safe as you might look at it). There seems to be a small variance in which side effects are more commonly seen, but those more severe side effects only seem to be an issue for certain particular pre-existing conditions. Advair was just not working, which is why I switched. The following paragraph can point as to why for me my doctor and I both think Dulera might be a better option.

    Advair is a larger particle size and travels slower and a shorter distance. This prevents it from absorbing as much into the smaller airpassages deep in the lungs. Dulera is a smaller particle which is also more evenly dispersed, hence has greater absorption in the lower parts of the lungs. This explains why in patients like myself, where the lower lungs are the issue, it has been claimed to be more effective. We’ll see, but I’m hopeful.

    As for HFA, the comments about the speed are right. HFA inhalers have a much lower speed when they exit the inhaler. This is actually better for inhalation as it also causes less chaotic airstreams, thus more medication actually reaching the lungs. HFA does not have the components in it however that can give you that “high” effect. I noticed a big difference when my proventil switched. I also noticed though that the allergen counts had been shifting higher as well as other pollutant counts. In addition, I found that my new proventil really only cut it with the spacing chamber. (on a side note look for the widest chamber you can find, it’s the width not distance that had a greater effect on the amount of medication lost in transit) Also, shake your new inhaler more vigorously than you might have the old CFC ones.

    Oh, with both Dulera and Advair you can get thrush. (they have steroids in them afterall) If your asthma or something else is compromising your breathing though, Advair will cause it more so. It has no propellant to aid the medication in reaching your lungs and not settling in your mouth/throat. And as I mentioned above, it’s larger, hence slower, particles.

    I hope this helps someone! Often I find knowing even a glimpse of some of the science behind a medication can help you decide to switch,start, etc and not leave you relying on your doctors experience or even another patient who’s cause might not realistically reflect your own.

  17. Anna says:

    I have COPD. I used Advair 250/50 from Oct. 2010-April 2011. I was still getting SOB and using oxygen. I was changed to Dulrea 100 in the middle of May. This medication is good(for me). I am now walking with little SOB don’t use my oxygen as much. On June 4th, was my second outing. I was able to walk a longer distance, but once I started walking up hill I havd to use oxygen @ 2Lpm, not the 4Lpm that I normally would use to walk when out. It was ok! I could feel better lung expansion.
    I could not do any of this using Advair.

  18. Amy says:

    I have had chronic and severe asthma since I was 5 years old and I will be 38 years old in September. I have been on everything from alupent, theophylline, proventil growing up to having to see a specialist in OKC because no doctor in my hometown could get my asthma under control. My symptoms have changed as an adult because I dont wheeze like I did as a child. Now my sypmotoms of an asthma flare are coughig and shortness of breath- much more difficult for me to pinpoint. I was on Advair as an adult for over 5 years but did not like the side effects (puffy face, dry cough and frequent upper respiratory infections that always moved to my lungs). So was weaned off Advair and Singulair 23 months ago and I was diong fine until this year. I had a bad asthma flare caused by a repiratory infection in January 2011 at which time I was put o oral prednisone, albuterol breathing treatments every 4-6 hours and antibiotics. I always use my pro air inhaler as needed which was only 2 days a week until January. Now, as of June 14th I am in the midst of another asthma flare and taking oral prednisone, antibiotics, breathing treatments. I asked my doctor about long-term control of my asthma and he gave me a sample of Dulera that I will try once this flare is over and I am breathing well again. I am excited and anxious about trying it because I know its new so it will be expensive but I’m hopeful that it will work for me. Since I was a child in the late 70s and early 80s when asthma treatment/ control was hard to find I am very thankful for all the new options I have for my treatment! =)

  19. Sam says:

    I have been on Dulera 200/5 now for about 4 months in an attempt to get my asthma under control after getting repeated episodes of thrush from Advair. I really can’t see a difference in the two but agree i tend to get a little relief much quicker with Dulera than i did with Advair.

    I’ve had asthma all my life but only began treatment for it in 2000. I was given Singular and Proventil and WOW…was I a new person, joined a gym and lost nearly 100lbs. Just in 2008 my symptoms began worsening and I was put on Advair, worked great for me for a while…until repeated thrush (even with rinsing as directed). Singular was a miracle drug for me!

    Yesterday I saw a new Pulmanologist….he is doing all the pulmonary function tests (which i’ve never had…i know..i couldn’t believe it either), blood test to check for allergic asthma, etc. One thing he did give me to try was an rx of Prilosec 40mg 1x daily an hour before evening meal. I took my first one last night and…well….this morning I felt…so…. good. I wasn’t all congested as usual and had lots more energy. I did a little research on GERD and Asthma and found that 80% of individuals with Asthma have GERD and that works visa/versa as well. So…I’m really hoping that this little improvement i’m feeling is going to continue…I’ve been to the point of taking my rescue inhaler 2-3 times a day.

    So, as far as Dulera….I haven’t seen a big improvement over Advair but i do feel better 15-30 mins after taking it with easier breathing. It just does not last the 12 hours i need it too.

    I pray for great health to us all….:-)

  20. David says:

    I find it interesting that with all the horrible pollutents in the world, the FDA decides CFC in our old inhalers are destroying the ozone layer.
    When you need rescue meds, you also need a propelent to send it deep into your lungs, When you cannot breathe, you do not have the luxury of a deep inhale of these powdered forms. When they replaced Albutrol with Pro Air, I noticed an immediate inability to recover from an attack. I switch back to Ventolin HFC. The pharmisist tried to give me Pro Air, even though my prescription said ” Ventolin” telling me it was the same. Its not! Its double the money of Ventolin and only works half as well. I scolded him for attempting to push something on me that was not on the prescription. To hell with the profit margins of these drug companys!

  21. Greg says:

    Though cfc”s in the old inhalers did have higher flow rates, if you ae not using a aerochamber this medication is deposited in the back of the throat. Using an aerochamber helps the meds rach deeper into the lungs not the cfc”s in the inhalers.

  22. scott says:

    I have used Advair for years with great success. Unfortunately my insurance provider will not pay for advair due to the extremely high price for the drug. They will pay for the Delura since it is much cheaper. Foradil (formoterol) is a much better long term bronchodilator that serevent (salmeterol). Foradil works just as fast as albuterol and has about the same effect on bronchodilation. Serevent takes a while to work and has less bronchodilator effect than albuterol. My only concern is if the steroid in Dulera is as effective as flovent. With advair I used 500/50, with the Dulera I am using the 100 dose with success. I really think that the better bronchodilator is the difference here.

  23. ante says:

    I was on Advair 500/50 & Albuterol for years & was still wheezing during the night during bad allergy seasons. I started Dulera in February & have not had any wheezing since. I still have my allergies, but without the wheezing. I started out at 2 puffs 2x per day, but now I only use it once a day. My doctor (Head Asthma doctor at Kaiser) told me they were having great success with Dulera & thought I would be a good candidate & would be able to cut down how many times I use it, as well. I am so glad that I changed to Dulera. It is cheaper in the long run, as I don’t have to use it twice a day, unless needed & most importantly it works for me.

  24. Ruth says:

    I’ve been using dulera for five months- loving it. I was on advair for over ten years. It became less and less effective during air pollution weeks etc. my symptoms included coughing, coughing when laughing, unable to sing or laugh without coughing. During allergies or a cold, uncontrollable coughing. Advair with a rescue inhaler just completely failed to handle it. I changed from allegra with advair and flonase, to astepro (as needed) antihistimine, singulair nightly, and dulera every twelve hours and flonase. The difference is unbelievable. I have my singing voice back. I can laugh. I can talk without coughing. I can walk a couple miles until I run out of time- not breath. Huge difference. No more rescue inhalers getting used up or used at all. thank you thank you thank you- dulera.

    when I was hiking the first summer I started advair, I noticed it opened my lungs to 800 on a peak flow, then dropped bam- while walking on a trail to 200, then reopened, etc. advair was the best they had- but using it was a freaky experience with regard to excersizing. I am not experiencing this with dulera- I just am- steady- and it doesn’t run out like advair – I was waking up at 4 am with advair, too soon to take the next dose having difficult time breathing. Now with dulera- I can simply breathe & be-
    why is it so much more effective for me? could it be the size of the particles or the method – its a puffer not a packet you breath in- initially especially with irritated and inflammation due to allergies and air pollution in addition to whatever lung issues inherent to the situation– it just went past the inflammation and deeper into lung tissue- without breath in being an issue- it flew in by itself basically all I have to do is aim and shoot while I breath.

    I am so relieved.

  25. Ruth says:

    Initially I used prendisone and z packs, then kenalog shots when I could not longer breath (which of course wore off.) I started with asthma cort & a separate seravent- which I liked, but everyone went to advair back then…. changing to singulair (smallest dose 10 something) helps-
    but for three months I used dulera alone with antihistime and no stingulair or oral steroid, or steroid shot- and the dulera stood alone changing my breathing. Its just different from advair. I think its about inflammation and advair not competing well with the particulate matter pollution etc. in the air- it failed. It became ineffective. I’m in for dulera.
    I think I can keep working with the career- I have a new voice for work. Its steady- its strong, I can breath all day long & I can keep my job. I’d been wondering about it.

  26. Ann says:

    1. There are histamine receptors in pulmonary and gastro tissue. Sam is correct, there is a large crossover between GERD and asthma.
    2. If you have inhaled or food allergies it is important to address your triggers (could also be weather, stress, exercise.) 3. Inhaled steroids are absorbed, to a lesser degree than oral steroids. 4. You can’t make a dosage comparison between different drugs, in terms of how much you are taking, That is, 100 ml of one drug does not necessarily compare to 100 ml of another, and a 200 ml does of one may not necessarily be stronger than a 100 ml of another. 5. There is not necessarily a direct correlation between potency and efficacy. In other words, a “stronger” drug may not work better than a “weaker” one. There are a lot of factors involved, pharmacokinetics and the pharmacodynamics (what the body does to a drug or what the drug does to the body.) 6. Use a spacer with inhaled albuterol. 7. Pulmonary functions tests: by the time you feel symptoms, your function is probably greatly decreased; it is important to get testing done and use peak flow meter. 8.Bart has very good information, thank you.

  27. Gloria McHenry says:

    My doctor recently put me on dulera. I haven’t noticed any positive chg from the advair. However, he also put me on Combivent for my rescue inhaler. This medication worked wonders for me. It has the albuterol like the old inhalers (only till 2013) had as well as another medication.

  28. Michael says:

    This is a great blog. I have been on Advair for several years but when I have a flare up it doesn’t help. I wish they would bring back Marax. Does anyone remember that? It was great. Just a simple pill once a day that took care of my asthma spendidly. I am sick of all the inhalers because I don’t think they actually do that much. I now just take lots of Mucinex and prilosec. And btw..my doc considers my asthma severe…but I am just sick and tired of all the inhaling, and my breathing function tests never improve. There has to be a better way. I say, please bring back the Marax!!!

  29. Shronda says:

    I have severe asthma,allergies and sinsus. I have tried basically ever drug that was prevented for allergy and asthma. I recently had surgery for my sinsuses and it help out a little. I was on advair, singular,astepro and xyzal all at once and I was still having problems. I recently changed to dulera,singular,nasonax and clarinex d and I have to take 2 allergy shots once a week .I have ventolin as a rescuer and I have albuterol sulfate to take in my plug inhaler. And so far everything has been fine. But like someone else mention I guess it all depends on the person.

  30. Greg says:

    I wanted to respond to a few of the comments left that aren’t accurate:

    Kerri – January 25th…Symbicort contains “budesonide”, a type of inhaled steroid similar to fluticasone and mometasone. Pulmicort also contains budesonide, although it is a different delivery device and formulation so the products should not be directly compared. When you say “weaker” I believe you are trying to describe the concept of “potency”. That is, the amount of a drug required to achieve a therapeutic effect. Potency, however, is NOT associated with efficacy (how well a drug works), so while budesonide is less potent than both fluticasone and mometasone, it does not work any less well.

    Chris – February 19th…There are no studies that compare formoterol to salmeterol, and therefore no basis to say that one has more severe systemic side effects. In fact, there is no difference between the two beyond how quickly they work. That is, they work via the same mechanism on the same receptor.

    Cathy – April 10th…Your description of inhaled steroids is simply inaccurate. Steroids, whether taken orally or through the lungs are absorbed in the blood stream and excreted through the kidneys and liver. They are not exhaled (except for the portion that is not deposited in the lungs and remains in the mouth or throat). The main difference is the way that your lung tissue absorbs and excretes these molecules which has a lesser effect on other similar receptors in the body compared to oral steroids.

    Overall, the best places to receive accurate information on medications are (its scary I know) from the manufacturers. Because of the high degree of regulation you can count on the information to be accurate and truthful, especially with companies like AstraZeneca (Symbicort) GSK (Advair) and Merck (Dulera). Every product has some possibility of adverse events.

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  33. Sprinkle apk says:

    An interesting communication is worth notice. I opine that you should write solon on this theme, it strength not be a preconception issue but mostly grouping are not enough to talk on much topics. To the succeeding. Cheers like your Tuesdays are Your Turn – Dulera vs. Advair.

  34. under cuvah brutha says:

    i have taken both. i can tell you that dulera opens me up much more without the annoying powder that fries the hell out of my throat. Advair doesn’t work as good at least taht has been my personal experience w.5/100 dulera vs. 100/50

  35. C-Love10 says:

    I have taken both Advair and Dulera. I stopped taken Advair because it irritated my Throat, but I always thought that Advair was the best asthma med I have ever been on. I wasnt too thrilled about the powder, but I thought it worked better than alot of the older asthma meds. I got switched to Dulera a couple months ago and I feel like I’m high when I take it. It gives me the jitters for hours, which in turn makes me feel tired and irritable. I found this blog to see if anyone else feels this way when they take Dulera. I’m not sure if it works better than Advair but i do know I didn’t felt nervous with taking Advair. But I’m not sure if I can go back on it, because of the throat Irriation. Horrible…

  36. Sue Farris says:

    Give us back our inhalers that worked! I have been struggling to breathe for months with asthma. I’ve had to see a Pulmonary Dr. who put me on a Prednisone burst. It worked the duration of the medicine and 3 days past the end of Prednisone. With all the air polution that
    could be cleaned up, why did they do away with the little bit of propellant in asthma inhalers??????

  37. charles m gomez says:

    have been on both advair and flovent meds. for a period of time.
    guestion are there really and safe asthma meds. out there with
    all the random side effects? just wondering.
    have a good all.

  38. Karen says:

    It’s good to hear about everyone’s experiences with asthma. Just today my dr. switched me over to Dulera from QVAR because I’ve been having flare ups over the past 3 months. I’ve had allergies all my life and adult onset of asthma in 1995 which was also around the same time I was diagnosed with GERD. I’m on an 8 week trial of Prilosec (to replace Ranitidine). I also eat a gluten free, dairy free diet because my heartburn would flare with gluten and dairy. I’m really resisting cutting out coffee because I love coffee (even decaf), but I think it will help the GERD which in turn will help the asthma. I don’t drink wine or beer because the sulfites trigger wheezing. I miss a cold hefeweizen in the hot summer with a slice of orange . . . oh well!

  39. Diane says:

    I have had severe asthma since I was a young child (now 48) I switched to Dulera 14 months ago and have significant improvement in my asthma symptoms. The only down side is a find that by 10 hours intomy dose I can feel it wanning and my symptoms starting to return. I take 2 puffs twice a day. I also use generic uniphyl. I do get thrush alot even though I gargled and brush my tongue after use. Itmay be that my Lupus makes it easier to develop thrush. I am very pleased with the meds!!

  40. Marie says:

    Great post! Love the feedback. So I just got switched over from my usual asthma+allergy meds. from 2008 till middle of last month. Qvar 40mcg, singulair 10 mg, and pro air hfa to dulera 2 puffs twice a day but I got to keep the other two. But I’ve noticed that my normally low immune system took a turn for the worse since starting dulera. I’ve gotten conjunctivitis 4 times in the last 5 weeks already but what worried me the most was last sunday I had a high fever, pressure in the inner ear (which affected both ears), chills, body aches, nausea, dizziness, nasal congestion, 4th case of conjunctivitis and sore throat an hour after my mom coughed nearby. So now I HAVE to take prednisone to fight of a viral immune virus in my own body (my doc said that virus is not contagious, it is my body attacking itself, but that the conjunctivitis is and that it’s going around this time of year). I know that that’s a side effect and everything but does anyone else have similar problems?

  41. Erika says:

    Stumbled across this site after googling ‘advair vs. dulera’. I’ve had asthma since I was 10 mos. old (now 40), so I have been through all the trial-and-error of new meds. After my first child was born 20 months ago, my asthma became out-of-control for the first time in 18 years. I’ve been on Advair 500/50 (one puff AM and PM), but my insurance company will no longer pay for it, switching all Advair patients to Dulera.
    My concern after reading the above messages is the jittery side effect of Dulera. I have a history of panic disorder, exacerbated by the asthma, and am a little nervous about switching over. Any other side effects or changes that people have noted after making the switch from Advair to Dulera? Thanks for a great blog!

  42. Carol says:

    I have a muscle disease. Consequently, my lungs are affected (decreased function). I’ve used Advair but had to use another inhaler with it. Dulera seems to be stronger and more effective for me. I have not experienced any side effects to my knowledge.

  43. Nina says:

    I just read the side effects with my daughter, and we are shocked to know that Dulera caused spinal bone reduction in 85%-88% of all patients using it. In children it causes growth reduction.
    Find something homeopathic, I will, I know it is there. Anyone who takes this regularly, will have some very serious side effects with bone breakage. Pregnant women will give birth to kids with a cleft palette, it caused it in mice and rats. Mice, rats and rabbits could not reproduce after being given Dulera. Pharmaceuticals are never the answer.
    We have to look into our lives and what we can do to reduce the allergens that cause Asthma and /or worsen it.

  44. Rose says:

    I have been using Advair and it didn’t help my symptoms last week. Had to go to the emergency room because the wheezing wouldn’t stop I have been using Dulera for two days and it has helped me. The side effects of Dulera are fat less than side effects of Advair. They all have side effects but my goal is to be on this short term.

  45. Heidi says:

    Those warnings are on the label because the FDA has concerns. However, I am a pharmacy student, and I would like you to know that asthma specialists do not have these concerns and feel that long acting beta agonists used in combination with an inhaled corticosteroid are fine. Growth in children only slows, and they may be a centimeter shorter than normal, but they will catch up eventually. Cleft palate is a possibility during birth, but the risks of having an acute asthma exacerbation while pregnant are much greater as this can cause harm to the fetus as they don’t receive enough oxygen. There are risks with every medication, but with the help of your doctor and pharmacist, you can alleviate those risks and get the most from your therapy. Avoidance of allergens is always a good thing to do, but some are unavoidable for some people, and we have to do the best we can.

  46. Joan says:

    I just started using Dulera (never used Advair) a few weeks ago for my Asthma. With the first time (of the higher dosage) I had a rotten headache, terrible shakiness and then my head felt really foggy and heavy. I called the pharmicist and he recommended waiting a few days and using the lower dose. I experienced the same reaction. Is there anything else that I can take that would not cause these reactions. (I have just been diagnosed with Asthma at 53, so this is all new to me).

  47. rick frea says:

    Interesting subject. My new asthma doctor said he thinks most asthmatics hate Advair — the medicine that made my hardluck asthma go away. He wanted me to try Symbicort or Dulera. He gave me a free Dulera. I tried it for a month. He said Symbicort and Dulera are the same because they both contain formoteral (a LABA). It was nice that the medicine worked fast to end an acute asthma episode, much faster than Advair. This was true, and nice. However, the side effects of Dulera were stunning. My heart raced after two puffs and I was jittery all day. This made me decide Advair was better for me. Advair never made me jittery and nervous and never increased my heart rate and force. And Advair gave me equal control over my asthma than Dulera. Advair is better. And that’s my opinion based on my personal experience.

  48. rick frea says:

    Allow me to add, however, that medicines work different for each patient. So all medicine should be available, and it should be up to the patient and the doctor to decide which one works best to control their asthma.

  49. rick frea says:

    Rose: I just wanted to say to you that it takes up to 2-3 weeks for any asthma controller medicine to get into your system. Most asthma experts, and most doctors, know it takes up to that long to know how the medicine will work for you. You may notice the side effects — if any — before you notice the benefits.

  50. liz says:

    whoever posted that dulera reduces bone density by 85-88% is wrong!!! those %s are referring to the FEV1 (or % of predicted lung function) of patients in the study, not the bone density!!!! *In a 2-year double-blind study in 103 male and female asthma patients 18 to 50 years of age previously maintained on bronchodilator
    therapy (Baseline FEV1 85%-88% predicted)*

    In another 2-year double-blind study in 87 male and female asthma patients 18 to 50 years of age previously
    maintained on bronchodilator therapy (Baseline FEV1 82%-83% predicted), treatment with mometasone furoate 400 mcg twice daily
    demonstrated no statistically significant changes in lumbar spine BMD at the end of the treatment period compared to placebo

  51. Mindy says:

    I used advair for years and it really helped me. Dulera has not helped me much, still have asthma issues while on it and it has cause a slew of side effects: dizziness, heavy filling in head, anxiety, nervousness, panic attacks and throat issues. Not to mention muscle weakness, etc. I am switching back over to Advair asap. I gave Dulera two months, so it is not like I am making a rash decision. Every patient is different, so it is always going to be trial and error with everyone. Use what works best for YOU.

  52. Bev Berg says:

    I had a recurrence of asthma during the fires and smoke in So Calif 2006. Plus a cat moved in. I was on Asmanex (corticosteroid) for over 3 years. Due to the price I only used it half the time I should’ve. Then a new doctor put me on Advair. At first it was great, never needed the rescue inhaler. THen it started not working as well. Now my HMO switched me to Dulera without any notice. The development of osteoporosis is common to all 3 meds. I’m 66 and of course have it, but part is family history as well as taking Prilosec (for ulcers) which has the same side effect. I read all the side effects of Dulera, and have the same concerns you all did. I haven’t started it yet. One day left on the Advair. Thanks for your input. I know now what to watch for.

  53. Patty says:

    I’m so glad I found this discussion. Just today my Dr. wanted to switch me from Advair 250/50 to Dulera so I am going to give Dulera a try. Advair has worked wonderfully for me but I have been on it for 18 months and I am concerned about long-term effects. I have only needed one dose (most days) of Advair the last several months and it works excellent. I will start the Dulera tomorrow and I hope I don’t have some of these side effects that I have read about. Time will tell. Thanks everyone for the info!

  54. Thierry Seeley says:

    Is anyone familiar with “aminophylline” treatment of asthma?

  55. kim Judd says:

    On December 26,2010 asthma almost stole my then five year old sons life.For eleven months my son took the strongest Advair inhaler. For eleven months my son had repetitive asthmatic bronchitis, pneumonia once, and would not hardly eat. After having pneumonia, my son Ryan’s doctor thought it best to place him on Dulera. I thank my sons doctor and Duleta for giving my now seven year old quality of life
    My sons peak flow levels went up 100 points, his Dr. Spots. Have gone from almost weekly to once in two to three months. In addition, my fears of my son eats and eats and has gained weight. For a mother, a huge weight had been lifted. My son finally is getting taller due to his ability to eat. Dulera has saved my son and inadvertently myself. I can’t thank Dulera enough. My son has quality of life back
    What better gift could I receive..or my son? Thank you Dulera! You are a life saver! Kim Judd for Ryan Allison, age 7.

  56. jane says:

    I had been on a Advair for a year when my HMO switched me to Dulera for “pharmaco-economic” reasons, i.e., they are getting Dulera cheaper. After just 2 weeks on Dulera, I am getting night (and sometimes day) dry coughs, which usually preceed an asthma attack. As of today, I am back on Advair. It’s hard to believe that the 2 drugs act so differently for me, but I am hoping they do (or else I will have to further investigate this cough).

  57. Tyler Rector says:

    I have tried many preventative inhalers including Advair. None of them ever seemed to work. I have been on Dulera for 2 months now and have not had to use my rescue inhaler for about the last 8 weeks. I am very active and before Dulera would have to use my resuce inhaler basically everyday to work out.

    I have had no side effects from Dulera. My Doctor recommended washing my mouth out prior to every use to avoid any possible throat issues.

  58. Brandi Gates says:

    My son was born with asthma and he tried every medication combo
    a little kid could handle. He did Flovent when he was younger and used
    His rescue inhaler often. For a couple years he was given allergy meds
    along with his Flovent to try to control the nightly coughs and frequent
    ER visits for croup.. About 12 years later he was given advair with
    Singular and for the last 3 years it has been wonderful. My son
    Is active and has been through out his life. Advair has made a huge
    Difference in his life BUT it costs us 275.00 per disk per month for
    Advair and 105.00 for singular per month. We have been waiting
    For a generic for advair so our insurance would cover it. We have
    Thousands of dollars in pharmacy bills but my son can be a
    Normal active boy. We were given dulera to start and I’m
    Very scared of new side effects or his asthma to not be controlled.
    Only time will tell..

  59. Rhonda says:

    News Flash… I was paying $40 for Dulera. Went to refill my Rx two days ago and it’s now $208.

  60. Danyal says:

    I am nervous to switch due to I have been on advair for 8 years and it has worked out great never woke up with spells or had an asthma attack in years my husband does not want me to switch so I don’t know what to do due to the cost differences

  61. Bert Bert says:

    I’ve used both Dulera and Advair. My body seems to respond better to Dulera. I’m giving Advair another try as I have a script for it, and my new insurance provider covers more of the cost. While I was in between insurance providers and job, I asked for samples. I was provided Dulera I immediately noticed a complete difference in quality of breathing. It made lifting weights, sprinting, playing football, and yoga easier. I have not had to hit the rescue inhailer in over six months while on Dulera. I am hoping since my lung capacity has dramatically changed in the six months, that Advair will have similar results. I would rather not have to use a rescue inhailer. My goal is to learn how to control my asthma through breathing exercise, fitness and loosing weight. I strongly recommend to practice yoga. There is a lot of breathing control needed, and it also teaches how to breath full lunged and to teach your body not to panic when it thinks you are out of air. It has been making a huge difference, and can’t wait for my semi-annual check up.

  62. Carol says:

    I have been on Advair 100/50 for about 6 years and recently it didn’t seem to help…so my doctor put me on Dulera… Right now I switch off..on a regular day I use advair but when i wake up and the asthma is bad I use dulera and it seems to work well. Not sure if i’m supposed to change off like that between the two but it is working and I’m happy.

  63. Sandy says:

    I had a stubborn double lung pneumonia and dulera helped cure me of it. My asthma is now more controlled, I rarely need the bronchodilater. Dulera is amazing. I feel I am alive because of it. I am so thankful my lung specialist talked me into it, I gave him a run for his money with recounting all the side effects and deaths. Thank God he gave me accurate advice. Persons who died were near death and under prescribed according to him. That made sense.

  64. dennis says:

    I’m in heating and air conditioning work and as I got older working around some of the moldiest dirtiest places I started haveing breathing problems. A lung dr. Had me try advair each morning, perfect no asthma not even a cold. I lost insurance and found out advair was over $300 so I asked for something else. Dr had me try dulera. I’ve tried it now for a few months and it has done nothing. Im using an inhaler several times a day. Have had a cold for four weeks. Wife got a new job and as soon as we get insurance I’m going back to advair.

  65. Escovedo says:

    I seriously take pleasure in your posts. Thank you

  66. ms says:

    I had a bout of pneumonia this past winter and after that cleared up I was still having serious issues with wheezing I was on a nebulizer 4 times a day and this wasn’t working so after numerous rounds of steroids doc finally put me on Dulera I was disappointed at first because it didn’t seem as thought it was working but by the third dose I could breath….. I have also been able to cut down the dose from two times a day to once a day I am a full time nursing student and a mother of 5 kids so the advantages this medications has given me compared to all the other treatments has been wonderful. I am still going to the pulmonologist this month as we are trying to figure out why I am wheezing as I have no past history of asthma.

  67. mary says:

    “you are ‘one cold away from death’ ” re: visit to an Asthma specialist ….Duera started and now nearly ‘dropped’, maybe once a week……cured??? have not coughed ONCE….this was adult on-set asthma with use of Xopenex and Chromolyn after dropping previous steroids……. nose/eye allergies since childhood before asthma started at 49

  68. Iiz says:

    I have been on advair 250/50 for over ten years. i never had asthma flare up’s when i was on it. I maybe went to the hospital once a year due to me over doing it and giving my self an asthma attack. I am on 3 different allergy and asthma medicines daily as well. I have had asthma since i was 5 and i have tried every trial and asthma medication in the last 20 years. as of may 1, 2013 my insurance provider decided that they wanted me off advair because it causes “too many asthma related deaths”. SO i have been off of my maintenance medications for over 3 weeks. My doctor gave me a prescription for qvar (which doesn’t work at all ) and now they want me to try Dulera, but apparently i have to get an authorization for Dulera because it is only supposed to be prescribed if a person has serious asthma. SO hopefully next week when i start Dulera it will help just as much as the advair did.

  69. Greg says:

    everyone with allergies and/or asthma should try eliminating take a shot at improving or eliminating there symptoms by trying NAET treatments.
    I had 32 treatments and haven’t used an inhaler since (25 years) and I have been able to do things I never could before getting the treatments. It has absolutely eliminated most of my allergies. read more on the Internet under NAET

  70. Mali says:

    I took Advair for a week and was allergic to it. I am on Dulera now, w/asthma but at least i can tolerate it.I am very concerned regarding sedi effects.Taking now rescue inhaler when needed.

  71. Scott says:

    I have been on advair for 10 years. Got new insurance and new script was denied and I had to try Dulera. I have not had good luck on the new med. Used it for month and went back to the doc today and wrote a new script for advair. will have to wait for the ins co to deny then appeal that it failed for me to get the approval. bottom line off a good med for over a month and now wheezing again. Hopefully I can get back on advair soon.

  72. Cheryl says:

    I was on Advair for a couple of years and did not notice much improvement; in fact, I noticed my asthma gradually getting worse. I was still functional, but needed my rescue inhaler about once a week. My doctor switched me to Dulara a couple of months ago and I noticed a remarkable improvement. I no longer feel like I have a 40 pound bag of cement on my chest at all times and have not needed my rescue inhaler ONCE since I started using it. However, it is freakishly expensive! My insurance doesn’t cover it. Anyone find a low cost source for this stuff?

  73. fred says:

    I have used planetdrugsdirect for my Advair before but got on a insurance plan that covered it. Now express scripts is not going to cover it for 2014. So it is back to the Canadian drugstore for my medications again.

  74. bob says:

    Fred: which Canadian drug store are you getting your Advair from? Still Planet Drugs?

  75. rhock says:

    Dulera is not for all.. tired it and had such horrible time I went back to Advair, Glaxo you need to stop charging to much, its stupid.

  76. mom of 4 with asthma... boo! says:

    Why is adult onset asthma hard to get control of! I’ve been trying to figure out how to get control of my asthma for 2 years, almost died of it. I’ve been on advair for 1.5 years… It has not helped… 25050, and now for the last year 50050. I take albuteral with the ipatropium … And I still need steroids to get me breathing with out wheezing seriously, but about 4-5 weeks later I’m at the wheezing point again. For anyone interested in buying their meds from Canada… Dr solve.com is a great legit online pharmacy… I have been buying advair 50050 for $87 per month… I don’t have insurance so this is a great deal. I’m going to ask my Dr about dulera… Praying I can get my life back… I have 4 wonderful children and a great husband I want to grow old with …

  77. Sherry says:

    I have tried everything…currently, I’m on Dulara …I feel so much better,. I feel normal…I don’t use my rescue inhaler hardly.

    That’s the good news…I’m also concern about weight gain…

    I was wondering WHY I’m gaining so much weight…and I’ve just read that Dulara has a steroid….so, I don’t know what to do….

    I’m already 25 on the BMI and that’s not good!

  78. Ann Marie says:

    I have been on Dulera 200 2 puffs twice a day for the past 8 months. My breathing has improved dramatically. The muscle/cramping has made using the Dulera impossible! New Year’s Day night I wasn’t able to sleep at all and decided life was too short to feet this bad. I’m on my way to pick up my first prescription of Advair

  79. Kim says:

    The reason why everyone’s insurance companies stopped covering Advair is because of new rules tied to Obamacare. Because Advair is a tier 3 drug (and most expensive for ins comp to cover) they want justification that you still need it. Stupid morons…my asthma is not miraculously going to go away so there’s your justification. So now if you want to stay on Advair you need to go to the dr and pay out co pays to keep getting it. Dulera is a tier 2 drug so it is cheaper. I was on Advair for YEARS with much success. Dulera, not so much. Gave it a couple of months but now going back to Advair. Only need to wait til 2016 for a generic Advair and then it will be a moot point.

  80. Aida says:

    Used Advair which really worked well for me for over 5 years, recently due to raise in Cost I was given Dulera, within 1 week of being off the Advair and using Dulera I ended up in the Er with an asthma attack. I need to get back on Advair. As per my insurance company dr can over-ride and reduce Cust just need their authorization.

  81. Lynnette says:

    @ Ann Marie,
    I take Advair and also have problems with muscle cramps. I have found that if I take calcium, magnesium and zinc supplement every day that the problem goes away. I take the dose recommended on the bottle. you might want to check with your Dr. first.

  82. Eileen says:

    My Aetna looser insurance will no longer cover my advair I have been n for 6 years. My asthma is controlled I only use it once daily unless I have a bad dust day or a bad cold. I almost never need a rescue inhaler. Why they have the right to make me go to dulera or symbicort when every commercial you see says if your asthma is controlled don’t take dulera ie don’t change what works. I have been going around the BS trying to find out who what why Aetna can make me do this with no reason but cause we want you to, Called ct insurance commission they say they can do that it’s legal. I asked who made it legal? I was told call my state legislator, which I did by email. That was a week ago, he emailed me back that I had a good question, but he didn’t know the answer and would get back to me. I just can;;t believe that an Insurance co can make you go off a med that is working perfect for you. They also can’t answer if I say try dulera and it doesn’t work do I then have to try symbicort before I can go back to advair??? again no one could answer. feeling like I am walking up a mountain, but I’m not stopping till I get all my questions answered. I’m really afraid to go off advair though, do I get to sue Aetna if I have a bad reaction or get bad asthma and end up in the emerg room??? Help,anyone out there know why this is happening.

  83. Michelle says:

    I have Aetna and have the same problem with ad air. It requires ore certification cup since Jan 2014. I tried symbicort, must the muscle cramping was too much for me. It actually was so bad that I had pulled muscles twice. I’m finishing my first week of dulera and it’s not working. Now I’ll be able to appeal and request Adair. Aetna said I would have to prove that dulera and symbicort don’t work to get preauthorization.. I’m afraid to knownhow much it’s going to cost, though!!!

  84. Christine says:

    My 82 yr. old mother has been taking advair for about 6 yrs. Just received notice from her prescription plan, Express Scripts, that advair, as of 4.1.14 is a non-preferred medication and they suggest dulera or symbicort as alternatives. My mother is deteriorating daily and will not be able to use the alternatives since they are in an inhaler form, she can’t physically use an inhaler, her hand is too weak and does not like someone doing it for her. She’s in a nursing home, hoping the nursing home will be able to make it so she can stay on the advair. Obamacare sucks and will kill off many, I guess that’s they plan! No death panels, think again!

  85. Jennifer says:

    I also was required by ins to switch from Advair and they prescribed Dulera, I have been on Advair, asthma free for 10 years! I am predicting Dulera won’t work but the good thing is they have step therapy so if it doesn’t work doc will re-prescribe Advair. Keeping fingers crossed, bad time of year to be changing in the spring

  86. Roberta says:

    After using Dulera 100/ 2 inhalations 2x daily only 2 times I had an allergic reaction to the Dulera and ended up in the hospital for 9 days!!!
    It may be good for some but it can be deadly as well. Proceed with caution!!

  87. SBL says:

    I tried Advair but it made my heart feel like it was racing. Dulera does not do that for me.

  88. Anna ways says:

    Obama care has nothing to do with your plans dropping advair! !
    Advair has been link to a high number of asthma related deaths. Its no longer a prefered drug. It hasn’t killed enough people pulled but there are safer options. nothing to do with obama care at all

  89. Anna ways says:

    Christine your mom doesn’t use the alternatives which are perfectly good drugs because she doesn’t like someone doing it for her. Get a spacer it a one way valve… pump the meds in and then hand it to her and she inhale them out in several cases it better to use a spacer….no on suggested that? ..not her dr ..hospital. .nursing home? If she’s so weak that she can’t pump an inhaler then someone must be there with her before she went into the nursing home so that person could have been doing this for her all along. there is no reason she can’t take those meds. If something isn’t working speak up and find a solution. May she feel better soon

  90. Al says:

    I was on Dulera for two years, and began having serious side effects, including nervousness, anxiety, trouble sleeping and dizziness. Asked my doctor to switch me to Advair, and have had no side effects yet. The bonus is that Dulera was costing me $95 / month co-pay, while Advair is only $45 / month. So far so good.

  91. Deana Y says:

    Al -if you don’t mind what insurance do you have ? I have had BC/BS and still had to pay 180 or so ( it kept going up) for a 3 month supply. Now we have aetna so there it goes.thanks in advance for your response!

  92. cynthia says:

    Believe it or not I’ve been on advair for 12 years! Just switched tonight, to dulera. My insurance wont pay of my advair anymore…. Wish me luck kinda worried. Praying it works.

  93. Jen a says:

    I was on advair for 12 years with great success. Because of insurance reasons, I had to switch to dulera. I have been on it for two months and have to use my rescue inhaler twice a day. I have numbess in my feet and hands, constant sore throats, and fatigue. I am calling the doctor tomorrow to get back on advair or try symbiotic.

  94. Cindy says:

    I have a 13 year old son who has been on dulera for 2 years now. He was on Flovent in the past but it didn’t seem to help him. Had a history bronchitis, pheunomonia and countless trips to ER for asthma attacks.It is the scariest thing in the world for a parent to see there child gasping for air. Since my son has been on Dulera his asthma attacks are rare. He is now able to participate in sports, and even runs the mile in PE class now. I also purchased a portable battery operated nebulizer for quick breathing treatments which works great. I highly recommend anyone with asthma to get one of these. They have the portable machines that run on 2 double D batteries. Great for outdoors, sports games, travel. Anywhere where electricity isn’t always accessible. They are kind of pricy but wore every penny! I purchased mine from medical supply store. But you can also find them on ebay.

  95. Lizzi says:

    Speaking from an outside perspective, it would seem that whilst Dulera works for some people, it definitely does not for others. In a similar fashion, where Advair is the best for some people, for others it is the worst.

    This is the same for all asthma medicines. I have been on Beclometasone (Clenil) for 3.5 weeks now, after months of rapidly worsening symptoms and using my rescue inhaler multiple times a day, and I am feeling an improvement already. However, my best friend used this as a child but now uses Fluticasone (Flixotide) because it was causing side effects in her, although my mum (who has eosinophilic bronchitis) has side effects from Flix and will probably need to change. Also, Salbutamol/Albuterol (Ventolin, Salamol etc.) are prescribed to basically every asthma patient and work for almost everyone, but it isn’t working for me, and the main issue there is that we don’t have Xopenex in the UK, and all the other bronchodilator (reliever) meds we have are in dry-powder form, which I can’t use, least of all when I’m having an attack.

    Like I say, I’m from the UK so I can’t give an opinion regarding Obamacare or co-pays and insurance, as we have the NHS so I don’t have to pay for medications, but I do feel strongly that all of you who have been told by insurance to try an inhaler that isn’t working for you should work with your doctor to formulate a strong appeal, as you should definitely be getting what works for you.

    I haven’t used Seretide (the UK’s version of Advair) or Dulera ever, so I can’t comment on that, but like I say, different things work for different people.

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  97. Meghan Campbell says:

    This is a great question! I am 34 years, I’ve had chronic asthma since I was 2 years old. Since Advair came out my life changed significantly. I’ve been taking Advair 250/50 for many years, but last year my allergist suggest I try Dulera. I have it a try for 2 months, my wheezing and chest tightness returned within 1 week of stopping Advair. I was using my rescue inhaler at least 1-2 times per day. After 2 months my allergist agreed that Advair was a better medication. I wished Dulera worked because Merck was providing it to me at no cost, but I’m back to paying my brand copay for Advair. With this medication I’m able to make my rescue inhaler last 6-12 months depending on the year. I say go with whatever works for you. Best of luck!

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  100. n/a says:

    I completely agree with Meghan Campbell. I had the same exact issue. My insurance company wanted me to change medications and within 3 days my lungs were in terrible painful condition. I was also having to take my rescue inhaler every 4-6 hours daily. I have given Dulera 2 months as well hoping that it would get better, but i finally gave up and contacted my doctor again. I am so happy to be back on Adair 250/50. Ultimately it will be whatever works best for you. Best wishes!

  101. Maggie Margulies says:

    Dulera is not working for me at all! I have been using my rescue inhaler constantly and I hardly ever used it while I was on the Advair. I don’t know what I am going to do. My doctor said my insurance provider wouldn’t cover Advair anymore.

  102. Amy says:

    This is in regards to Dulera.. My 16 year old was switched over from Advair to Dulera due to the cost difference. My son was on Dulera for almost a year, when we started to notice to severe weight loss. They were thinking it was something in his GI, but after all the testing and being down to a weight of 82 pounds he was admitted into Childrens Hospital where he was there for 2 weeks. What we did find is that Dulera caused severe thrush all over his asophogus, also causing an infection internally attacking his immune system. Since he has been off Dulera he has gained his weight back and we haven’t seen any more of these issues. I would never advise anyone to switch to Dulera after the side effects it has caused my son.

  103. Humberto Galvez says:

    I have had chronic asthma since I was a baby, at the age of 12 I started using rescue inhaler Ventolin only, but after 29 years of using ventolin my rescue inhaler was not helping me at all. Last year my doctor Prescribed me Dulera it had helped me tremendously that I haven’t used my rescue inhaler not even once. I haven’t notice any side effect and is already 1 year and 1 month that I have been taking dulera. the only thing that I don’t like is that is costing $256 to my insurance.

  104. Valfreyja says:

    As for me, Dulera has been a wonderful medication. My asthma was so out of control for months that I couldn’t draw a full breath and ended up in the ER when my back muscles basically just gave out from the stress of trying to force a breath into these beat up lungs. I have exhibited minor and passing sensitivities to beta 2 agonists so I have chosen to try Dulera in small steps and so far, I’ve had no adverse reactions of any sort. I’m up to half the typical dose, twice a day, and already my asthma is WAY better controlled. I haven’t used my rescue inhaler since I started it.

    By all accounts, I should have been one of the people who reacted poorly to Dulera given my history of rapid heart rate and panic attacks when using Albuterol. But It’s caused me no trouble what so ever. SO I have to repeat what was said better above in that you really cannot take another person’s advice on what works and what doesn’t. Your body chemistry is different and what’s going to make your life worth living might make mine a living nightmare, and vice versa. No one wants to hear that, and I know all too well how very very long a day is when every breath is a battle. But you just have to try it and see. Keep an open mind, remember these medicines take as much as 2 weeks to work for many people (though with long acting Beta 2 agonists it can be as soon as the very first dose as it was with me).

    Dulera hit the “off” switch on my asthma and maybe it can for you all too. I wish you all only the best and hope you get to know my relief just as soon as possible.

  105. Mike says:

    I’ve had asthma since I was a young child and carried around different rescue inhalers my entire life. Last year I had a several cold and it triggered an 2 asthma attacks in 1 day. Previous to that, I hadn’t had a non-allergy related attack in 5 years. I had a breathing treatment in Urgent care, had a second attack hours later, another breathing treatment and was managing.

    I hadn’t been to my asthma doctor in some time, I know this was my fault, but aside from these attacks, my asthma was controlled with a rescue inhaler. When I went for a visit, we spoke, and he put me on Dulera. I don’t know how to say it, other than it has changed my life. I would use my inhaler 1-4 times a day, during any physical activity, just constantly. With Dulera, I started 1 puff in the morning and at night and that’s it. To this day, I haven’t touched my rescue inhaler 1 time. I ref soccer, and play softball every week, I can run and do whatever with no issues. During sports, I keep my rescue in my bag, but I don’t even carry my inhaler when I leave the house any more. For those who have done it their whole lives, you’ll know how liberating that feeling is. Fortunately, I haven’t had any side effects that others have mentioned, but the only issue I have is the cost. Extremely expensive, about $240 with insurance.

  106. victoria says:

    Maggie, tell your doctor to writ an appeal letter that states you can not use Dulera and only Advair medically works for you. Insurance can’t force you to take a med that is not working.

  107. Glenn says:

    I started taking Adair 15 years ago, just 6 months after quitting Cigarette smoking. The Diskette worked so well, I didn’t need the full 2 daily doses, some days I’d forget with no major issues. After three days or so I would notice my breathing change and the wheeze would return slightly, but enough to get me back to my daily dose…
    THEN, Obama care came along and sure enough, the Insurance carrier decided their money making shenanigans were more important than having happy healthy participants!
    They refused to pay for the Adair at a preferred price and basically forced me into Dulera..
    I never used it before so I didn’t argue…
    OMG.. Every day since I started, it’s been like going three days at a time without Advair…I have to use the rescue almost every night…so…I call the Doc, tell him to arbitrate the insurance.
    HERE is where I answer Victoria…
    The Insurance carrier can’t deny you from getting what you want but they won’t pay the preferred price…so now I pay 50%.. whI checked is 160.00 more than I use to pay for 3 months worth of Advair Before Obama care. …Praying For Change!!!

  108. Debra G. says:

    I have had chronic asthma since I was a child I am now 57 years old. Some people out grow asthma, but I didn’t. I have been on many different meds throughout the years – Singular, Advair, Symbicort and I was given some Dulera samples by my primary doctor after an especially bad episode of phumonia. I was shocked after using Dulera my asthma actually leveled out & I felt like a normal person. I had no attacks and didn’t even need to use my inhaler for over a year. But once my Dr was unable to provide any samples I was put on Symbicort, this was ok but it is not nearly as good as the Dulera. I hope a generic version comes along soon or else another alternative. Struggling to breathe normally really hampers my ability to enjoy things. My lungs are so damaged I was told they look like a heavy smoker and I have NEVER picked picked up a cigarette. I cannot even be in the same room as anyone who smokes. Every breathe I can take is precious to me. But I can’t afford the cost of the Dulera.

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